Cheapest GLP-1 over 12 months
The cheapest first month is rarely the cheapest year. Intro rates expire and annual prepay locks you in, so compounded semaglutide usually wins the twelve-month total.
The cheapest GLP-1 over a full year is rarely the one with the cheapest first month. Compounded semaglutide usually carries the lowest twelve-month total. The table below ranks every program by what a year actually costs, checked every Monday.
Some links here earn us a commission. Prices checked Monday, August 24, 2026.
22 programs with a verified price, ranked by what a full year costs. The first-year total counts the introductory rate for as long as it runs, then the maintenance price. Checked Aug 31, 2026.
| Program | Supply | First month | Per month after | First year total |
|---|---|---|---|---|
| Strut Health | Compounded | $149 | $149 | $1,788 |
| Found | Either | $169 | $169 | $2,028 |
| Mochi Health | Compounded | $138 | $178 | $2,096 |
| Ivim Health | Either | $175 | $175 | $2,100 |
| Shed | Either | $199 | $199 | $2,388 |
| Calibrate (plan copay) | Branded | $224 | $224 | $2,688 |
| Noom Med | Either | $129 | $249 | $2,868 |
| WeightWatchers Clinic | Branded | $25 for 3 months | $373 | $3,432 |
| Lemonaid Health | Compounded | $298 | $298 | $3,576 |
| Amazon Pharmacy | Branded | $299 | $299 | $3,588 |
| Knownwell | Branded | $299 | $299 | $3,588 |
| Medvi | Compounded | $299 | $299 | $3,588 |
| Sam's Club Member Health | Branded | $299 | $299 | $3,588 |
| Hone Health | Compounded | $315 | $315 | $3,780 |
| CVS MinuteClinic | Branded | $328 | $328 | $3,936 |
| GoodRx for Weight Loss | Branded | $338 | $338 | $4,056 |
| Walgreens Weight Management | Branded | $348 | $348 | $4,176 |
| Ro Body | Branded | $188 | $373 | $4,291 |
| Costco / Success by Sesame | Branded | $358 | $358 | $4,296 |
| Sesame Care | Either | $358 | $358 | $4,296 |
| Hims & Hers | Branded | $188 | $448 | $5,116 |
| LifeMD | Branded | $188 | $448 | $5,116 |
Over a full year the range runs from $1,788 at Strut Health to $5,116 at LifeMD. Compare all 22 on the chart.
Why the cheapest month is not the cheapest year
A low first month is a hook. Some programs charge $25 or $99 to start, then jump to a higher maintenance price after a month or two, so a program that wins month one can sit near the bottom over twelve. The first-year figure above counts the intro rate for as long as it runs, then the regular price.
Annual prepay lowers the monthly price and locks you in
Paying twelve months up front cuts the monthly price and can produce the lowest number on the chart. The trade is commitment: most annual plans are non-refundable once the medication ships. Prepay if you expect to continue. Go month-to-month, which costs more each month, if you might stop.
Where compounded fits
Compounded semaglutide from a licensed US pharmacy is usually the lowest ongoing price and the lowest twelve-month total, and the cheapest legitimate route for most cash payers. Our compounded pharmacy comparison lists what each one charges.
Compare the first-year total, not the headline first month: the full ranked chart is on our homepage, the state view at cheapest GLP-1 by state, and the month-by-month math in our guide to maintenance dose costs.
Compounded semaglutide usually wins the year. See Strut's score and today's price on the Strut Health review page.
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