A study testing whether a GLP-1 medicine from University of Colorado, Denver, semaglutide, can help with weight.
What this means for you
- Who can join
- Ages 12 to 45, have obesity, BMI 35+.
- What you take
- semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 4.9 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Obesity/Therapy.
Full scientific study title: Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity.
Who can join
Ages 12 to 45, have obesity, BMI 35+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- English-speaking
- male or female (sex assigned at birth)
- 12-18 y/o with obesity (BMI>120% of the 95th %ile)
- 30-45 y/o with obesity (BMI>35 kg/m2)
Key exclusion criteria
- treated with glucagon-like peptide-1 (GLP-1) agonists (e.g., exenatide, liraglutide, semaglutide, tirzepatide) for weight management in the prior 3 months
- currently taking anti-psychotic medications (anti-depressants accepted)
- diagnosis of type 2 diabetes
- current or lifetime anorexia nervosa or current bulimia nervosa
- head injury resulting in loss of consciousness >30min
Where this study is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Colorado1 site
- University of Colorado Anschutz Medical CampusAurora, Colorado
Timeline
Started enrolling: 2026-05-01. Expected completion: 2031-04-30. Last updated on ClinicalTrials.gov: 2025-06-15.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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