Enrolling now · NCT07446439

A study testing whether tradipitant from Vanda Pharmaceuticals, an investigational anti-nausea medicine, can reduce nausea and vomiting.

What this means for you

Who can join: Adults 18 to 65, have nausea and vomiting, BMI 25+.
What you take: Tradipitant, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The study runs about 9 months.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 3Sponsor Vanda PharmaceuticalsDrug TradipitantClass OtherSites 10 USEnrollment target 280

What this study is for

Primary condition: Nausea and Vomiting. Also studied in: Obesity.

Full scientific study title: A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use.

Who can join

Age18 to 65SexAnyBMI25 to 40

Adults 18 to 65, have nausea and vomiting, BMI 25+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Body Mass Index >= 25 and < 40 kg/m^2
No serious medical problems or chronic diseases, specifically no type I or type II diabetes

Key exclusion criteria

Another disorder that contributes to gastrointestinal symptoms
History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
Exposure to any investigational medication within the past 60 days

Where this study is enrolling

This trial has 10 sites across 6 states. Contact a site coordinator directly to start screening.

Find a site near you

California3 sites

Vanda Investigational Site
Los Angeles, California
Vanda Pharmaceuticals202-734-3400
Vanda Investigational Site
San Diego, California
Vanda Pharmaceuticals202-734-3400
Vanda Investigational Site
San Jose, California
Vanda Pharmaceuticals(202) 734-3400

Florida1 site

Vanda Investigational Site
Tampa, Florida
Vanda Pharmaceuticals(202) 734-3400

New Jersey1 site

Vanda Investigational Site
Hamilton, New Jersey
Vanda Pharmaceuticals(202) 734-3400

New York2 sites

Vanda Investigational Site
New York, New York
Vanda Pharmaceuticals202-734-3400
Vanda Investigational Site
Syosset, New York
Vanda Pharmaceuticals(202) 734-3400

Texas2 sites

Vanda Investigational Site
Plano, Texas
Vanda Pharmaceuticals(202) 734-3400
Vanda Investigational Site
San Antonio, Texas
Vanda Pharmaceuticals(202) 734-3400

Virginia1 site

Vanda Investigational Site
Burke, Virginia
Vanda Pharmaceuticals(202) 734-3400

Follow this trial

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Timeline

Started enrolling: 2026-03-27. Expected completion: 2026-12-01. Last updated on ClinicalTrials.gov: 2026-04-20.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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