A study testing whether a GLP-1 medicine from Lilly, orforglipron, can lower blood pressure.
What this means for you
- Who can join
- Adults 18+, have high blood pressure.
- What you take
- orforglipron, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 2.4 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Hypertension.
Full scientific study title: A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2.
Who can join
Adults 18+, have high blood pressure. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- refer to the GZPL master protocol study for screening eligibility.
Key exclusion criteria
- refer to the GZPL master protocol study for screening eligibility.
Where this study is enrolling
This trial has 28 sites across 18 states. Contact a site coordinator directly to start screening.
Arizona1 site
- Elite Clinical Studies, LLCPhoenix, Arizona
California2 sites
- Valley Clinical Trials, Inc.Covina, California
- Valley Clinical Trials, Inc.Northridge, California
Connecticut1 site
- Chase Medical Research, LLCWaterbury, Connecticut
Florida4 sites
- Excel Medical Clinical TrialsBoca Raton, Florida
- Care Access - BrandonBrandon, Florida
- Northeast Research Institute - Downtown OfficeJacksonville, Florida
- Peace River Cardiovascular CenterPort Charlotte, Florida
Hawaii1 site
- East-West Medical Research InstituteHonolulu, Hawaii
Maryland2 sites
- Sinai Hospital Of BaltimoreBaltimore, Maryland
- Ascension Saint Agnes Heart CareBaltimore, Maryland
Massachusetts1 site
- Lucida Clinical TrialsNew Bedford, Massachusetts
Michigan1 site
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, Michigan
Missouri1 site
- StudyMetrix ResearchCity of Saint Peters, Missouri
Nevada2 sites
- Excel Clinical Research, LLCLas Vegas, Nevada
- Palm Research Center SunsetLas Vegas, Nevada
New York1 site
- Rochester Clinical Research, LLCRochester, New York
Ohio1 site
- Remington-Davis, IncColumbus, Ohio
Oregon1 site
- Advanced Research Institute - TigardTigard, Oregon
South Carolina1 site
- Care Access - MauldinMauldin, South Carolina
Texas3 sites
- Dallas Heart and Vascular Consultants, PADuncanville, Texas
- Texas Institute of Cardiology, PAMcKinney, Texas
- North Hills Family Medicine/North Hills Medical ResearchNorth Richland Hills, Texas
Utah1 site
- Advanced Research InstituteOgden, Utah
Virginia3 sites
- Carient Heart & Vascular - ManassasManassas, Virginia
- Health Research of Hampton Roads, Inc.Newport News, Virginia
- National Clinical Research, IncRichmond, Virginia
Washington1 site
- Eastside Research AssociatesRedmond, Washington
Timeline
Started enrolling: 2025-04-30. Expected completion: 2027-09. Last updated on ClinicalTrials.gov: 2026-04-17.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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