A study testing whether a GLP-1 medicine from Lilly, orforglipron, can reduce bladder leaks.
What this means for you
- Who can join
- Adults 18+, women only, have stress urinary incontinence (bladder leaks), BMI 27+.
- What you take
- orforglipron, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 2.5 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Urinary Incontinence,Stress.
Full scientific study title: A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight.
Who can join
Adults 18+, women only, have stress urinary incontinence (bladder leaks), BMI 27+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have a diagnosis of stress urinary incontinence
Key exclusion criteria
- Have had urinary incontinence surgery
- Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
- Have given birth within one year of screening
- Have had a change in body weight of more than 11 pounds within 90 days prior to screening
- Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening
Where this study is enrolling
This trial has 21 sites across 11 states. Contact a site coordinator directly to start screening.
Alabama2 sites
- University of Alabama -The Kirklin ClinicBirmingham, Alabama
- AMR ClinicalMobile, Alabama
Arizona1 site
- Urologic Surgeons of ArizonaMesa, Arizona
California3 sites
- Matrix Clinical ResearchLos Angeles, California310-424-5922
- Alarcon Urology CenterMontebello, California
- Prestige Medical GroupTustin, California
Colorado1 site
- Colorado Clinical ResearchLakewood, Colorado303-996-9649
Florida4 sites
- AMR ClinicalFort Myers, Florida239-936-4421
- Altus ResearchLake Worth, Florida561-641-0404
- New Age Medical Research CorporationMiami, Florida305-596-9901
- Emerald Coast OBGYN Clinical ResearchPanama City, Florida
Georgia1 site
- Teak Research ConsultsLawrenceville, Georgia
Michigan1 site
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, Michigan248-312-0025
Pennsylvania2 sites
- OB/GYN Associates of ErieErie, Pennsylvania
- Clinical Research of PhiladelphiaPhiladelphia, Pennsylvania215-676-6696
Texas2 sites
- Next Level Urgent CareHouston, Texas832-460-3311
- Innovative Medical Research of TexasHouston, Texas
Virginia2 sites
- Health Research of Hampton Roads, Inc.Newport News, Virginia757-591-8100
- Urology of VirginiaVirginia Beach, Virginia
Washington2 sites
- Northwest Clinical Research CenterBellevue, Washington877-453-0404
- Seattle Clinical Research CenterSeattle, Washington206-522-3330
Timeline
Started enrolling: 2025-09-30. Expected completion: 2028-03. Last updated on ClinicalTrials.gov: 2026-05-22.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
Other GLP-1 clinical trials
Back to the full directory → or take the matching quiz if you want clinical trials filtered to your conditions and location.
